整个幻灯片组织学图像中的组织类型学注释是一项复杂而乏味但既繁琐但必要的任务，用于开发计算病理学模型。我们建议通过将开放式识别技术应用于共同分类属于一组带注释类的组织的任务来解决此问题。临床相关的组织类别，同时拒绝测试时间开放式样品，即属于训练集中不存在的类别的图像。为此，我们引入了一种基于训练模型的开放式组织病理图像识别的新方法，以准确识别图像类别，并同时预测已应用了哪些数据增强变换。在测试时间中，我们测量了模型的置信度预测这种转换，我们期望开放集中的图像较低。在组织学图像的结直肠癌评估的背景下，我们进行了全面的实验，这些实验为我们的方法提供了证据，以自动从未知类别中识别样品的优势。代码在https://github.com/agaldran/t3po上发布。

Multimodal deep learning has been used to predict clinical endpoints and diagnoses from clinical routine data. However, these models suffer from scaling issues: they have to learn pairwise interactions between each piece of information in each data type, thereby escalating model complexity beyond manageable scales. This has so far precluded a widespread use of multimodal deep learning. Here, we present a new technical approach of "learnable synergies", in which the model only selects relevant interactions between data modalities and keeps an "internal memory" of relevant data. Our approach is easily scalable and naturally adapts to multimodal data inputs from clinical routine. We demonstrate this approach on three large multimodal datasets from radiology and ophthalmology and show that it outperforms state-of-the-art models in clinically relevant diagnosis tasks. Our new approach is transferable and will allow the application of multimodal deep learning to a broad set of clinically relevant problems.

The success of Deep Learning applications critically depends on the quality and scale of the underlying training data. Generative adversarial networks (GANs) can generate arbitrary large datasets, but diversity and fidelity are limited, which has recently been addressed by denoising diffusion probabilistic models (DDPMs) whose superiority has been demonstrated on natural images. In this study, we propose Medfusion, a conditional latent DDPM for medical images. We compare our DDPM-based model against GAN-based models, which constitute the current state-of-the-art in the medical domain. Medfusion was trained and compared with (i) StyleGan-3 on n=101,442 images from the AIROGS challenge dataset to generate fundoscopies with and without glaucoma, (ii) ProGAN on n=191,027 from the CheXpert dataset to generate radiographs with and without cardiomegaly and (iii) wGAN on n=19,557 images from the CRCMS dataset to generate histopathological images with and without microsatellite stability. In the AIROGS, CRMCS, and CheXpert datasets, Medfusion achieved lower (=better) FID than the GANs (11.63 versus 20.43, 30.03 versus 49.26, and 17.28 versus 84.31). Also, fidelity (precision) and diversity (recall) were higher (=better) for Medfusion in all three datasets. Our study shows that DDPM are a superior alternative to GANs for image synthesis in the medical domain.

The availability of challenging benchmarks has played a key role in the recent progress of machine learning. In cooperative multi-agent reinforcement learning, the StarCraft Multi-Agent Challenge (SMAC) has become a popular testbed for centralised training with decentralised execution. However, after years of sustained improvement on SMAC, algorithms now achieve near-perfect performance. In this work, we conduct new analysis demonstrating that SMAC is not sufficiently stochastic to require complex closed-loop policies. In particular, we show that an open-loop policy conditioned only on the timestep can achieve non-trivial win rates for many SMAC scenarios. To address this limitation, we introduce SMACv2, a new version of the benchmark where scenarios are procedurally generated and require agents to generalise to previously unseen settings (from the same distribution) during evaluation. We show that these changes ensure the benchmark requires the use of closed-loop policies. We evaluate state-of-the-art algorithms on SMACv2 and show that it presents significant challenges not present in the original benchmark. Our analysis illustrates that SMACv2 addresses the discovered deficiencies of SMAC and can help benchmark the next generation of MARL methods. Videos of training are available at https://sites.google.com/view/smacv2

Recent advances in computer vision have shown promising results in image generation. Diffusion probabilistic models in particular have generated realistic images from textual input, as demonstrated by DALL-E 2, Imagen and Stable Diffusion. However, their use in medicine, where image data typically comprises three-dimensional volumes, has not been systematically evaluated. Synthetic images may play a crucial role in privacy preserving artificial intelligence and can also be used to augment small datasets. Here we show that diffusion probabilistic models can synthesize high quality medical imaging data, which we show for Magnetic Resonance Images (MRI) and Computed Tomography (CT) images. We provide quantitative measurements of their performance through a reader study with two medical experts who rated the quality of the synthesized images in three categories: Realistic image appearance, anatomical correctness and consistency between slices. Furthermore, we demonstrate that synthetic images can be used in a self-supervised pre-training and improve the performance of breast segmentation models when data is scarce (dice score 0.91 vs. 0.95 without vs. with synthetic data).

部署到现实世界的自主智能代理必须与对感官输入的对抗性攻击保持强大的态度。在加强学习中的现有工作集中于最小值扰动攻击，这些攻击最初是为了模仿计算机视觉中感知不变性的概念。在本文中，我们注意到，这种最小值扰动攻击可以由受害者琐碎地检测到，因为这些导致观察序列与受害者的行为不符。此外，许多现实世界中的代理商（例如物理机器人）通常在人类主管下运行，这些代理商不容易受到这种扰动攻击的影响。结果，我们建议专注于幻觉攻击，这是一种与受害者的世界模式一致的新型攻击形式。我们为这个新颖的攻击框架提供了正式的定义，在各种条件下探索了其特征，并得出结论，代理必须寻求现实主义反馈以对幻觉攻击具有强大的态度。

合作多代理设置中的标准问题设置是自我播放（SP），其目标是训练一个很好地合作的代理团队。但是，最佳SP政策通常包含任意惯例（“握手”），并且与其他受独立训练的代理商或人类不兼容。后者的Desiderata最近由Hu等人正式化。 2020年作为零射击协调（ZSC）设置，并以其其他游戏（OP）算法进行了部分解决，该算法在纸牌游戏Hanabi中显示出改进的ZSC和人类表现。 OP假设访问环境的对称性，并防止代理在训练过程中以相互不相容的方式破坏它们。但是，正如作者指出的那样，发现给定环境的对称性是一个计算困难的问题。取而代之的是，我们通过简单的K级推理（KLR）Costa Gomes等人表明。 2006年，我们可以同步训练所有级别，我们可以在哈纳比（Hanabi）获得竞争性的ZSC和临时团队表现，包括与类似人类的代理机器人配对。我们还引入了一种具有最佳响应（SYKLRBR）的新方法，即同步的K级推理，该方法通过共同培训最佳响应来进一步提高同步KLR的性能。

尽管受到监督的深度学习彻底改变了语音和音频处理，但它必须为个人任务和应用程序方案建立专业模型。同样，很难将其应用于仅可用标记数据的方言和语言。自我监督的代表学习方法承诺一个单一的通用模型，该模型将使各种各样的任务和领域受益。这种方法已显示出在自然语言处理和计算机视觉域中的成功，在减少许多下游场景所需的标签数量的同时，达到了新的性能水平。语音表示学习在三个主要类别中也经历了类似的进展：生成，对比和预测方法。其他方法依赖于多模式数据，用于预训练，将文本或视觉数据流与语音混合。尽管自我监督的语音表示仍然是一个新生的研究领域，但它与用零词汇资源的声学单词嵌入和学习密切相关，这两种资源已经进行了多年的积极研究。这篇评论介绍了自我监督的语音表示学习及其与其他研究领域的联系的方法。由于许多当前的方法仅集中在自动语音识别作为下游任务上，因此我们回顾了基准测试的最新努力，以将应用程序扩展到语音识别之外。

骨关节炎（OA）是影响全球人口大量比例的最常见的联合障碍，主要是老年人。尽管其个人和社会经济负担，但仍然无法可靠地预测OA的发病和进展。旨在填补这种诊断缺口，我们介绍了基于生成模型的无监督学习计划，以预测基于膝关节X线本的OA的未来发展。使用来自骨关节炎研究的纵向数据，我们探讨了潜在的时间轨迹，以预测患者未来的射线照片，达到八年的随访访问。我们的模型预测了对OA的进展的风险，并超越了其监督对应物，其投入由七位经验丰富的放射科医师提供。通过支持模型，灵敏度，特异性，阳性预测值和负预测值显着增加到42.1％至51.6％，从72.3％到88.6％，从28.4％到57.6％，83.9％至88.4％，分别在没有这种支撑的情况下，放射科医生仅比随机猜测更好地进行。尽管需要在训练阶段没有人为注释，但我们的预测模型可以提高对OA发作和进展的预测。

双目标多模式共享问题（BIO-MMCP）的目的是确定旅行的最佳运输分配方式，并安排可用汽车和用户的路线，同时最大程度地减少成本并最大程度地提高用户满意度。我们从以用户为中心的角度研究了生物MMCP。由于用户满意度是共享移动性系统中的关键方面，因此我们在第二个目标中考虑用户偏好。用户可以在一天中的不同时间选择并对其首选的运输方式进行排名。通过这种方式，我们可以解释整个计划范围内的不同交通状况。我们研究问题的不同变体。在基本问题中，用户必须实现的任务顺序是预先固定的，旅行时间以及偏好在计划范围上是恒定的。在变体2中，引入了与时间有关的旅行时间和偏好。在变体3中，我们在允许其他路由决策时检查了挑战。变体4集成了变体2和3。在最后一个变体中，我们开发了一种分支和切割算法，该算法嵌入了两个双向目标框架中，即$ \ epsilon $ -constraint方法和一种加权二进制搜索方法。计算实验表明，分支和切割算法的表现优于MIP公式，我们讨论了沿Pareto边境的更改解决方案。